Frontotemporal dementia linked to chromosome 3.
نویسندگان
چکیده
A large pedigree with autosomal dominant frontotemporal dementia has been identified. Positional cloning has linked the disease gene to the pericentromeric region of chromosome 3. Clinical, neuropsychological, imaging, pathological and molecular genetic data are presented. The genetic mutation responsible for the disease has not been identified.
منابع مشابه
Tau protein in frontotemporal dementia linked to chromosome 3 (FTD-3).
Recent work on frontotemporal dementia (FTD) has revealed the existence of at least 3 genetically distinct groups of inherited FTD: FTDP-17, FTD and motor neuron disease linked to chromosome 9, and FTD linked to chromosome 3 (FTD-3). Tau, on chromosome 17, is the only gene where mutations have been identified and its involvement in FTD has been firmly established. The genes on chromosome 9 and ...
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عنوان ژورنال:
- Dementia and geriatric cognitive disorders
دوره 17 4 شماره
صفحات -
تاریخ انتشار 2004